Maria G Castro Selected Research

Ganciclovir (Cytovene)

1/2018	Evolutionary basis of a new gene- and immune-therapeutic approach for the treatment of malignant brain tumors: from mice to clinical trials for glioma patients.
1/2016	Preclinical Efficacy and Safety Profile of Allometrically Scaled Doses of Doxycycline Used to Turn "On" Therapeutic Transgene Expression from High-Capacity Adenoviral Vectors in a Glioma Model.
3/2014	Temozolomide does not impair gene therapy-mediated antitumor immunity in syngeneic brain tumor models.
9/2013	Effectiveness and preclinical safety profile of doxycycline to be used "off-label" to induce therapeutic transgene expression in a phase I clinical trial for glioma.
10/2012	Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.
10/2009	Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression.
7/2009	GENE THERAPY FOR THE TREATMENT OF PITUITARY TUMORS.
1/2009	HMGB1 mediates endogenous TLR2 activation and brain tumor regression.
4/2008	Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials.
7/2007	Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.

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Maria G Castro Research Topics

Disease

75	Neoplasms (Cancer) 05/2022 - 11/2002
72	Glioma (Gliomas) 11/2022 - 11/2002
28	Brain Neoplasms (Brain Tumor) 10/2022 - 12/2004
22	Glioblastoma (Glioblastoma Multiforme) 11/2022 - 11/2006
11	Herpes Simplex 01/2017 - 08/2005
5	Encephalitis (Encephalitis, Rasmussen) 01/2017 - 04/2002
4	Diffuse Intrinsic Pontine Glioma 12/2020 - 01/2017
4	Melanoma (Melanoma, Malignant) 01/2018 - 01/2009
4	Infections 01/2017 - 04/2002
3	Wounds and Injuries (Trauma) 04/2010 - 12/2003
3	Inflammation (Inflammations) 07/2007 - 04/2002
2	Brain Stem Neoplasms (Brain Stem Tumor) 12/2020 - 01/2020
2	Disease Progression 01/2020 - 05/2013
2	Pituitary Neoplasms (Pituitary Adenoma) 07/2009 - 12/2005
1	Epilepsy (Aura) 01/2020
1	Gliosis 01/2020

Drug/Important Bio-Agent (IBA)

17	Thymidine KinaseIBA 01/2020 - 11/2002
15	flt3 ligand protein (flt3 ligand)IBA 01/2020 - 12/2004
13	Proteins (Proteins, Gene)FDA Link 11/2022 - 01/2009
10	LigandsIBA 01/2022 - 08/2005
10	Ganciclovir (Cytovene)FDA LinkGeneric 01/2018 - 07/2007
9	CytokinesIBA 01/2021 - 06/2010
9	Temozolomide (Temodar)FDA LinkGeneric 01/2021 - 01/2009
9	Phosphotransferases (Kinase)IBA 01/2019 - 04/2008
8	antiglomerular basement membrane antibodyIBA 01/2022 - 01/2009
8	AntigensIBA 01/2020 - 12/2004
7	Pharmaceutical PreparationsIBA 01/2021 - 11/2002
6	DNA (Deoxyribonucleic Acid)IBA 10/2021 - 02/2015
6	AntibodiesIBA 01/2018 - 04/2008
6	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 01/2017 - 08/2005
5	ChromatinIBA 11/2022 - 10/2009
5	Galectin 1 (LGALS1)IBA 01/2021 - 09/2014
5	Neoplasm Antigens (Tumor Antigens)IBA 01/2021 - 04/2008
5	ProdrugsIBA 01/2021 - 11/2002
5	EnzymesIBA 08/2020 - 11/2002
5	Immunotoxins (Immunotoxin)IBA 10/2011 - 01/2005
4	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 11/2022 - 01/2019
4	dipinacoline glutamateIBA 12/2020 - 01/2017
4	VaccinesIBA 09/2017 - 01/2014
3	Peptides (Polypeptides)IBA 07/2021 - 01/2020
3	Histones (Histone)IBA 01/2021 - 01/2017
3	RNA (Ribonucleic Acid)IBA 12/2020 - 01/2017
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 10/2009
3	HMGB1 Protein (HMG1)IBA 01/2018 - 01/2009
2	ChemokinesIBA 01/2022 - 10/2012
2	alpha-hydroxyglutarateIBA 10/2021 - 01/2021
2	Immune Checkpoint InhibitorsIBA 01/2021 - 01/2020
2	epidermal growth factor receptor VIIIIBA 01/2021 - 01/2014
2	Therapeutic UsesIBA 01/2021 - 01/2018
2	activin AIBA 12/2020 - 01/2020
2	Biological ProductsIBA 01/2020 - 07/2014
2	HDL LipoproteinsIBA 01/2020 - 01/2019
2	TransposasesIBA 01/2020 - 01/2020
2	Protein Isoforms (Isoforms)IBA 01/2020 - 01/2018
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 10/2019 - 06/2014
2	Bevacizumab (Avastin)FDA Link 01/2018 - 07/2014
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018 - 07/2014
2	Small Interfering RNA (siRNA)IBA 12/2016 - 11/2015
2	EpitopesIBA 10/2016 - 06/2005
2	Doxycycline (Periostat)FDA LinkGeneric 01/2016 - 09/2013
2	LectinsIBA 11/2015 - 09/2014
2	Antineoplastic Agents (Antineoplastics)IBA 06/2014 - 11/2010
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2012 - 03/2008
2	NF-kappa B (NF-kB)IBA 10/2012 - 09/2003
2	InterferonsIBA 10/2012 - 08/2012
2	Immunoglobulin G (IgG)IBA 10/2012 - 04/2010
2	Immunoglobulins (Immunoglobulin)IBA 10/2011 - 01/2009
2	Heptanol (1 Heptanol)IBA 04/2010 - 02/2010
2	Glycyrrhizic Acid (Glycyrrhizin)IBA 07/2009 - 01/2009
2	beta-Galactosidase (Lactaid)IBA 07/2007 - 09/2003
2	adenovirus receptorIBA 09/2006 - 04/2002
1	CannabidiolIBA 05/2022
1	Histone DemethylasesIBA 10/2021
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 10/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 01/2021
1	cariporideIBA 01/2021
1	atezolizumabIBA 01/2021
1	gamma-glutamylaminomethylsulfonic acid (GAMS)IBA 01/2021
1	Messenger RNA (mRNA)IBA 12/2020
1	Eosine Yellowish-(YS) (Eosin)IBA 12/2020
1	cresyl violetIBA 12/2020
1	Sucrose (Saccharose)IBA 12/2020
1	Fatty Acids (Saturated Fatty Acids)IBA 08/2020
1	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 08/2020
1	Ketone BodiesIBA 08/2020
1	Antigen-Antibody Complex (Immune Complex)IBA 07/2020
1	Proto-Oncogene Proteins c-fynIBA 01/2020
1	Bumetanide (Bumex)FDA LinkGeneric 01/2020
1	Cancer VaccinesIBA 01/2020
1	Member 2 Solute Carrier Family 12IBA 01/2020
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2020

Therapy/Procedure

50	Therapeutics 11/2022 - 12/2004
27	Immunotherapy 01/2022 - 01/2005
8	Drug Therapy (Chemotherapy) 01/2020 - 10/2009
7	Radiotherapy 01/2022 - 10/2009
4	Aftercare (After-Treatment) 07/2009 - 04/2008
2	Transplantation 01/2020 - 01/2004
1	Lasers (Laser) 12/2020
1	Ketogenic Diet 08/2020